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Ziprasidone hydrochloride

3085 3 Citations Datasheet / COA / SDS
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Ziprasidone hydrochloride | CAS No. 122883-93-6 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: CP 88059

Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).

Technical Data

M.Wt:
449.4
Formula:
C21H21ClN4OS.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
122883-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citations for Ziprasidone hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:

3 Citations: Showing 1 - 3

  1. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Mediators Inflamm  2015;10:e0141829
  2. Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.
    Authors: Canfrán-Duque Et al.
    J Lipid Res  2013;54:310
  3. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol  2012;167:1480

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VersaClone cDNA Plasmids

Human 5-HT2A (NP_000612) VersaClone cDNA

RDC0288

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