Catalog Number: 3085
Alternate Names: CP 88059
Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Biological Activity
Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.
    Seeger et al.
    J.Pharmacol.Exp.Ther., 1995;275:101
  2. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile.
    Schmidt et al.
    Eur.J.Pharmacol., 2001;425:197
  3. Investigation into the effects of the novel antipsychotic ziprasidone on weight gain and reproductive function in female rats.
    Fell et al.
    Behav.Brain Res., 2005;160:338

The citations listed below are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:

Showing Results 1 - 3 of 3

  1. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Mediators Inflamm
  2. Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.
    Authors: Canfrán-Duque Et al.
    J Lipid Res
  3. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol
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