Ziprasidone hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:3085
Alternate Names:CP 88059
Chemical Name:5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).
Technical Data
  • M.Wt:
    449.4
  • Formula:
    C21H21ClN4OS.HCl
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    138982-67-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
    Authors: Canfrán-Duque Et al.
    Mediators Inflamm  2015;10:e0141829
  2. Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.
    Authors: Canfrán-Duque Et al.
    J Lipid Res  2013;54:310
  3. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol  2012;167:1480

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