Ziprasidone hydrochloride
Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Purity: ≥99%
Biological Activity
Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Ziprasidone (CP-88,059): a new antipsychotic with combined DA and serotonin receptor antagonist activity.
Seeger et al.
J.Pharmacol.Exp.Ther., 1995;275:101 -
Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile.
Schmidt et al.
Eur.J.Pharmacol., 2001;425:197 -
Investigation into the effects of the novel antipsychotic zipras. on weight gain and reproductive function in female rats.
Fell et al.
Behav.Brain Res., 2005;160:338
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Citations for Ziprasidone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:
3 Citations: Showing 1 - 3
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Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
Authors: Canfrán-Duque Et al.
Mediators Inflamm 2015;10:e0141829
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Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.
Authors: Canfrán-Duque Et al.
J Lipid Res 2013;54:310
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First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
Authors: Schulz Et al.
Br J Pharmacol 2012;167:1480
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