ZM 306416 hydrochloride

Key Product Details

Product Description

ZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC₅₀ values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for ZM 306416 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZM 306416 hydrochloride

The following data is based on the product molecular weight 370.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.01 mL	135.06 mL	270.12 mL
0.5 mM	5.40 mL	27.01 mL	54.02 mL
1 mM	2.70 mL	13.51 mL	27.01 mL
5 mM	0.54 mL	2.70 mL	5.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Hennequin Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 1999 PMID: 10639280

Product Documents for ZM 306416 hydrochloride