Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50
values are 100 nM and 2 μ
M respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo
Soluble to 10 mM in DMSO
Desiccate at RT
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Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Hennequin et al.
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