ZM 306416 hydrochloride
Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
Biological ActivityZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.
Hennequin et al.
Citations for ZM 306416 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:
5 Citations: Showing 1 - 5
Regulation of breast cancer induced bone disease by cancer-specific IKKβ.
Authors: Marino Et al.
Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish.
Authors: Zhang Et al.
Dis Model Mech 2016;9:1383
Endothelial cells enhance the migration of bovine meniscus cells.
Authors: Yuan Et al.
Arthritis Rheumatol 2015;67:182
Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
Authors: Crouch Et al.
J Biomol Screen 2015;35:4528
FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling.
Authors: Lee Et al.
Nat Commun 2014;5:5583
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