ZM 306416 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2499
Chemical Name:4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
Technical Data
  • M.Wt:
    370.21
  • Formula:
    C16H13N3O2FCl.HCl
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    196603-47-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Endothelial cells enhance the migration of bovine meniscus cells.
    Authors: Yuan Et al.
    Arthritis Rheumatol  2015;67:182
  2. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
    Authors: Crouch Et al.
    J Biomol Screen  2015;35:4528
  3. FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling.
    Authors: Lee Et al.
    Nat Commun  2014;5:5583

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