Coactosin-like Protein 1/CotL1 Proteins and Enzymes

Coactosin-like Protein (CotL1) is a cytoskeletal protein that is part of the ADF/Actin Depolymerizing Factor family of actin-binding proteins. Human CotL1 is 142 amino acids (aa) in length with a predicted molecular weight of approximately 16 kDa. It shares 95% aa sequence identity with the mouse and rat orthologs.  It is principally composed of one ADF-H domain (aa 2-130) that contains a phosphorylation site at Ser115, and two acetylation sites at Lys102 and Lys126. There is one potential ...