Fucosyltransferase 11/FUT11 Proteins and Enzymes

Fucose is frequently found at terminal sites on various glycans and is essential for the generation of many sugar epitopes. Well-known fucose containing glycans include Lewis and ABO blood group antigens. Lewis epitopes are key elements involved in leukocyte homing and extravasation process, thus are essential for lymphocyte maturation and natural defense functions. O-fucosylation on Notch receptor is found to be essential for its signaling function. So far, 11 carbohydrate specific ...