PTP pi/PTPRU Proteins and Enzymes

Protein Tyrosine Phosphatase, receptor type U (PTPRU), also called PCP-2 or PTPpi, is a type IIb receptor-like protein tyrosine phosphatase (PTPR). The extracellular domain contains MAM, Ig-like C-type and Fibronectin III domains that often mediate cell adhesion, but unlike other family members, PTPRU does not appear to mediate homophilic cell aggregation. It does, however, antagonize Wnt signaling in adherens junctions by inhibiting beta-catenin-mediated gene transcription.