Sirtuin 1/SIRT1 Activity Assays

Sirtuin 1 (SIRT1) is an NAD+dependent class III histone deacetylase. It is a member of the sirtuin family of proteins, homologous to the yeast Sir2 protein. SIRT1 modulates intracellular activities through transcription regulation and functions in several separate cellular functions. SIRT1 deacetylates and inactivates tumor suppressor protein p53, ...