SPRY4 Proteins and Enzymes

SPRY4 (sprouty 4) is a member of the sprouty family of proteins. It blocks tyrosine kinase growth factor activation of the MAPK signaling pathway, possibly through an interaction with either Raf1 or TESK1. Human SPRY4 is 322 amino acids (aa) in length. It contains three SH3-binding domains (aa 3-9; 25-31; 168-174), an NLS (aa 87-93), a PEST sequenc...