ZEB2/SIP1 Proteins and Enzymes

SIP1 (Smad-interacting protein 1), also called Zeb-2 (Zinc finger E-box-binding homeobox 2), is a nuclear transcription factor. SIP1 contains seven C2H2-type zinc finger domains, a Smad-MHZ binding domain, an atypical homeobox domain, and phosphorylation, sumoylation and acetylation sites. SIP1 is highly expressed in postmitotic neocortical cells a...