1-Naphthyl PP1

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1-Naphthyl PP1 | CAS No. 221243-82-9 | Src Family Kinase Inhibitors
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Description: Src family kinase inhibitor; also inhibits c-Abl
Alternative Names: 1-NA-PP 1

Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥99%

Product Details
Citations (6)

Biological Activity

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A chemical switch for inhibitor-sensitive alleles of any protein kinase.
    Bishop et al.
    Nature, 2000;407:395
  2. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
    Bishop et al.
    J.Am.Chem.Soc., 1999;121:627

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Citations for 1-Naphthyl PP1


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