1-Naphthyl PP1

Key Product Details

Product Description

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC₅₀ values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC₅₀ values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Product Specifications for 1-Naphthyl PP1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 1-Naphthyl PP1

The following data is based on the product molecular weight 317.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.75 mL	78.77 mL	157.53 mL
1 mM	3.15 mL	15.75 mL	31.51 mL
2 mM	1.58 mL	7.88 mL	15.75 mL
10 mM	0.32 mL	1.58 mL	3.15 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Bishop Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc.
• Bishop A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000 PMID: 11014197

Product Documents for 1-Naphthyl PP1