Catalog Number: 3063
Alternate Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Technical Data
  • M.Wt:
    317.39
  • Formula:
    C19H19N5
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    221243-82-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A chemical switch for inhibitor-sensitive alleles of any protein kinase.
    Bishop et al.
    Nature, 2000;407:395
  2. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
    Bishop et al.
    J.Am.Chem.Soc., 1999;121:627
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
    Authors: Meyer Et al.
    Genes Dev 2015;26:2986
  2. Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.
    Authors: Chen Et al.
    PLoS Biol 2015;13:e1002329
  3. Dual mechanisms prevent premature chromosome segregation during meiosis.
    Authors: Kim Et al.
    Cell Death Dis 2013;27:2139
  4. Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.
    Authors: Lo and Hollingsworth
    Methods Mol Biol 2011;745:135

Have you used 1-Naphthyl PP1?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information