1-Naphthyl PP1

Catalog # Availability Size / Price Qty
3063/10
3063/50
Src Family Kinase Inhibitors Small Molecule
1 Image
Description: Src family kinase inhibitor; also inhibits c-Abl
Alternative Names: 1-NA-PP 1

Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Technical Data

M.Wt:
317.39
Formula:
C19H19N5
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
221243-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A chemical switch for inhibitor-sensitive alleles of any protein kinase.
    Bishop et al.
    Nature, 2000;407:395
  2. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
    Bishop et al.
    J.Am.Chem.Soc., 1999;121:627

Product Datasheets

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Citations for 1-Naphthyl PP1

The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

5 Citations: Showing 1 - 5

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