1-Naphthyl PP1

  ( 5 citations )    
Product Datasheet
Catalog Number:3063
Alternate Names:1-NA-PP 1
Chemical Name:1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Product Details
Citations (5)
Reviews
Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Technical Data
  • M.Wt:
    317.39
  • Formula:
    C19H19N5
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    221243-82-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
    Authors: Meyer Et al.
    Genes Dev  2015;26:2986
  2. Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.
    Authors: Chen Et al.
    PLoS Biol  2015;13:e1002329
  3. A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture.
    Authors: Suhandynata Et al.
    G3 (Bethesda)  2014;4:2125
  4. Dual mechanisms prevent premature chromosome segregation during meiosis.
    Authors: Kim Et al.
    Cell Death Dis  2013;27:2139
  5. Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.
    Authors: Lo and Hollingsworth
    Methods Mol Biol  2011;745:135

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used 1-Naphthyl PP1?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee