Catalog Number: 3063
Alternate Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A chemical switch for inhibitor-sensitive alleles of any protein kinase.
    Bishop et al.
    Nature, 2000;407:395
  2. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
    Bishop et al.
    J.Am.Chem.Soc., 1999;121:627

The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

Showing Results 1 - 4 of 4

  1. Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
    Authors: Meyer Et al.
    Genes Dev
  2. Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.
    Authors: Chen Et al.
    PLoS Biol
  3. Dual mechanisms prevent premature chromosome segregation during meiosis.
    Authors: Kim Et al.
    Cell Death Dis
  4. Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.
    Authors: Lo and Hollingsworth
    Methods Mol Biol
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