Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Biological Activity Selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
Soluble to 25 mM in DMSO and to 50 mM in ethanol
Store at RT
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