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17-PA

Catalog #: 2681 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2681/10
2681/50
17-PA | CAS No. 694438-95-4 | GABA-A Receptor Modulators
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Description: Antagonist of neurosteroid potentiation and direct gating of GABAA

Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol

Purity: ≥99%

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Biological Activity

17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.

Technical Data

M.Wt:
350.54
Formula:
C25H34O
Solubility:
Soluble to 25 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
694438-95-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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