Catalog Number: 2681
Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Biological Activity
Selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol.
    Kelley et al.
    Eur.J.Pharmacol., 2007;572:94
  2. Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors.
    Mennerick et al.
    Mol.Pharmacol., 2004;65:1191
  3. Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor.
    Akk et al.
    Mol.Pharmacol., 2007;71:461
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