Selective antagonist of neurosteroid potentiation and direct gating of GABAA
receptors. Selectively reduces the effects of 5α
-reduced steroids compared to 5β
-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α
-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
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Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol.
Kelley et al.
Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors.
Mennerick et al.
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor.
Akk et al.