Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Biological Activity17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
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Complete Your Research
Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors.
Mennerick et al.
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor.
Akk et al.
Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol.
Kelley et al.
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