Catalog Number: 5945
Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Biological Activity
Endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This product is sold in units of 359μg, equivalent to 0.5μmol.
Background References
  1. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
    Zhang et al.
    Mol.Cell., 2013;51:226
  2. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
    Downey et al.
    PLoS One, 2014;9:e99988
  3. Rat and human STINGs profile similarly towards anticancer/antiviral compounds.
    Zhang et al.
    Sci.Rep., 2015;5:18035
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