Chemical Name: 3-Bromo-2-oxopropanoic acid
Biological Activity3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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