3-Bromopyruvate

Key Product Details

Product Description

3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC₅₀ = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.

Product Specifications for 3-Bromopyruvate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 3-Bromopyruvate

The following data is based on the product molecular weight 166.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.99 mL	29.95 mL	59.89 mL
5 mM	1.20 mL	5.99 mL	11.98 mL
10 mM	0.60 mL	2.99 mL	5.99 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol. Dis. 2022 PMID: 34973450
• Vander Linden Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 2021 PMID: 34077729

Product Documents for 3-Bromopyruvate