Chemical Name: 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Biological ActivityPotent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Williams-Karnesky et al.
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.
Massillon et al.
Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
Parkinson and Geiger
Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
Ugarkar et al.
Citations for 5-Iodotubercidin
The citations listed below are publications that use Tocris products. Selected citations for 5-Iodotubercidin include:
6 Citations: Showing 1 - 6
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Authors: Baron Et al.
Am J Physiol Renal Physiol 2015;6:e1629
Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
Authors: Rüben Et al.
PLoS One 2015;10:e0132453
Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate.
Authors: Visentin Et al.
Mol Pharmacol 2012;82:209
Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
Authors: Prakasam Et al.
J Neurosci 2012;303:F279
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Cell Death Dis 2011;339:886
Adenosine kinase regulation of cardiomyocyte hypertrophy.
Authors: Fassett Et al.
Am J Physiol Heart Circ Physiol 2011;300:H1722
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