5-Iodotubercidin

  ( 6 citations )    
Product Datasheet
Catalog Number:1745
Chemical Name:5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Product Details
Citations (6)
Reviews
Biological Activity
Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
Technical Data
  • M.Wt:
    392.15
  • Formula:
    C11H13IN4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >90
  • Storage:
    Store at -20°C
  • CAS No:
    24386-93-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-Iodotubercidin include:

6 Citations: Showing 1 - 6
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  1. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Am J Physiol Renal Physiol  2015;6:e1629
  2. Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
    Authors: R&#252;ben Et al.
    PLoS One  2015;10:e0132453
  3. Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate.
    Authors: Visentin Et al.
    Mol Pharmacol  2012;82:209
  4. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
    Authors: Prakasam Et al.
    J Neurosci  2012;303:F279
  5. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Cell Death Dis  2011;339:886
  6. Adenosine kinase regulation of cardiomyocyte hypertrophy.
    Authors: Fassett Et al.
    Am J Physiol Heart Circ Physiol  2011;300:H1722

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