Catalog Number: 1745
Chemical Name: 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Biological Activity
Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
Technical Data
  • M.Wt:
    392.15
  • Formula:
    C11H13IN4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >90%
  • Storage:
    Store at -20°C
  • CAS No:
    24386-93-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
    Parkinson and Geiger
    J.Pharmacol.Exp.Ther., 1996;277:1397
  2. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.
    Massillon et al.
    Biochem.J., 1994;299:123
  3. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
    Ugarkar et al.
    J.Med.Chem., 2000;43:2883
  4. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
    Williams-Karnesky et al.
    J.Clin.Invest., 2013;123:3552
Citations:

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