Potent adenosine kinase inhibitor (IC50
= 26 nM). Also nucleoside transporter inhibitor (IC50
values are < 25 nM, 7 μ
M and 15 μ
M for inhibition of [3
H]uridine and [3
H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50
values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μ
M respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
Parkinson and Geiger
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.
Massillon et al.
Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
Ugarkar et al.
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Williams-Karnesky et al.
The citations listed below are publications that use Tocris products. Selected citations for 5-Iodotubercidin include:
Showing Results 1 - 6 of 6