5,7-Dichlorokynurenic acid sodium salt

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3698/10
3698/50
5,7-Dichlorokynurenic acid sodium salt | CAS No. 1184986-70-6 | NMDA Receptor Antagonists
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Description: Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid

Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

Purity: ≥98%

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Biological Activity

Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Technical Data

M.Wt:
280.04
Formula:
C10H4Cl2NNaO3
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1184986-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
    Baron et al.
    Mol.Pharmacol., 1990;38:554
  2. Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
    Moore et al.
    Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;

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