Catalog Number: 3698
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Biological Activity
Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).
Technical Data
  • M.Wt:
    280.04
  • Formula:
    C10H4Cl2NNaO3
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1184986-70-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
    Baron et al.
    Mol.Pharmacol., 1990;38:554
  2. Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
    Moore et al.
    Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;
Tocris Small Molecules
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5,7-Dichlorokynurenic acid

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