Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Biological Activity5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).
Sodium Salt also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
Baron et al.
Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
Moore et al.
Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;
Citations for 5,7-Dichlorokynurenic acid
The citations listed below are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:
4 Citations: Showing 1 - 4
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Authors: Adamsky Et al.
An excitatory GABA loop operating in vivo.
Authors: Astorga Et al.
Front Cell Neurosci 2015;9:275
Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina.
Authors: Stevens Et al.
Cell Commun Signal 2010;21:239
The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
Authors: Kenny Et al.
J Biol Chem 2009;284:324
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