Catalog Number: 0286
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Biological Activity
Potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Sodium salt (Cat. No. 3698) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
    Baron et al.
    Mol.Pharmacol., 1990;38:554
  2. Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
    Moore et al.
    Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;

The citations listed below are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:

Showing Results 1 - 3 of 3

  1. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci
  2. Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina.
    Authors: Stevens Et al.
    Cell Commun Signal
  3. The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
    Authors: Kenny Et al.
    J Biol Chem
Tocris Small Molecules
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5,7-Dichlorokynurenic acid sodium salt

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