Catalog Number: 3826
Alternate Names: 7,8-DHF
Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological Activity
Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
Technical Data
  • M.Wt:
    254.24
  • Formula:
    C15H10O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    38183-03-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.
    Jiang et al.
    Hum.Mol.Genet., 2013;22:2462
  2. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats.
    Andero et al.
    Hippocampus, 2012;22:399
  3. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
    Jang et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:268
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:

7 Citations: Showing 1 - 7
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  1. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling 2016;14:23
  2. Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins.
    Authors: Chitranshi Et al.
    Purinergic Signal 2015;16:21087
  3. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
    Authors: Al-Qudah Et al.
    Am J Physiol Gastrointest Liver Physiol 2014;306:G328
  4. TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
    Authors: Meltser Et al.
    Curr Biol 2014;24:658
  5. Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs.
    Authors: Choi Et al.
    Muscle Nerve 2013;59:450
  6. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.
    Authors: Abcejo Et al.
    Int J Mol Sci 2012;7:e44343
  7. The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
    Authors: Mantilla and Ermilov
    PLoS One 2012;45:274

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