Catalog Number: 3826
Alternate Names: 7,8-DHF
Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological Activity
Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.
    Jiang et al.
    Hum.Mol.Genet., 2013;22:2462
  2. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats.
    Andero et al.
    Hippocampus, 2012;22:399
  3. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
    Jang et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:268
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