7,8-Dihydroxyflavone

  ( 8 citations )    
Product Datasheet
Catalog Number:3826
Alternate Names:7,8-DHF
Chemical Name:7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
Technical Data
  • M.Wt:
    254.24
  • Formula:
    C15H10O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    38183-03-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:

8 Citations: Showing 1 - 8
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  1. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  2. Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins.
    Authors: Chitranshi Et al.
    Purinergic Signal  2015;16:21087
  3. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
    Authors: Chen Et al.
    Eur J Neurosci  2014;39:1439
  4. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
    Authors: Al-Qudah Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;306:G328
  5. TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
    Authors: Meltser Et al.
    Curr Biol  2014;24:658
  6. Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs.
    Authors: Choi Et al.
    Muscle Nerve  2013;59:450
  7. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.
    Authors: Abcejo Et al.
    Int J Mol Sci  2012;7:e44343
  8. The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
    Authors: Mantilla and Ermilov
    PLoS One  2012;45:274

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