Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Biological Activity Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Store at +4°C
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