Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd
= 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro
and in vivo
. Exhibits neuroprotective effects in an HD mouse model.
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Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.
Jiang et al.
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats.
Andero et al.
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
Jang et al.
The citations listed below are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:
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