Chemical Name: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Biological ActivityA 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia.
Loeder S, Zenz T, Schnaiter A et al.
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost et al.
Citation for A 410099.1
The citations listed below are publications that use Tocris products. Selected citations for A 410099.1 include:
1 Citation: Showing 1 - 1
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Authors: Susanne Et al.
Front Cell Dev Biol 2022;10:886537
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