Chemical Name: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Biological ActivityHigh affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia.
Loeder S, Zenz T, Schnaiter A et al.
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Oost et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for A 410099.1
There are currently no reviews for this product. Be the first to review A 410099.1 and earn rewards!
Have you used A 410099.1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image