A 77636 hydrochloride

Key Product Details

Product Description

A 77636 hydrochloride is a potent and selective dopamine D₁-like receptor agonist (pEC₅₀ values are 8.97 and < 5 for D₁-like and D₂-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

Product Specifications for A 77636 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 77636 hydrochloride

The following data is based on the product molecular weight 365.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.66 mL	27.33 mL
5 mM	0.55 mL	2.73 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Kebabian A-77636: a potent and selective DA D₁ receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol. 1992 PMID: 1362704
• Lewis Homologous desensitization of the D_1A DA receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther. 1998 PMID: 9655879
• Acquas The potent and selective DA D₁ receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol. 1994 PMID: 7957630

Product Documents for A 77636 hydrochloride