Catalog Number: 1701
Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Biological Activity
Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.
Technical Data
  • M.Wt:
    365.9
  • Formula:
    C20H27NO3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    145307-34-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat.
    Acquas et al.
    Eur.J.Pharmacol., 1994;260:85
  2. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.
    Kebabian et al.
    Eur.J.Pharmacol., 1992;229:203
  3. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
    Lewis et al.
    J.Pharmacol.Exp.Ther., 1998;286:345
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
    Authors: Guha Et al.
    J Neurochem 2012;122:823

Have you used A 77636 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information