A 77636 hydrochloride
Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[184.108.40.206,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride
Biological ActivityA 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The potent and selective DA D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat.
Acquas et al.
Homologous desensitization of the D1A DA receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
Lewis et al.
A-77636: a potent and selective DA D1 receptor agonist with antiparkinsonian activity in marmosets.
Kebabian et al.
Citations for A 77636 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:
5 Citations: Showing 1 - 5
The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.
Authors: Lee Et al.
J Neuroinflammation 2018;15:286
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making.
Authors: Zalocusky Et al.
Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
Authors: Guha Et al.
J Neurochem 2012;122:823
Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.
Authors: Chan Et al.
Mol Cell Proteomics 2012;11:M111.016642
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