A 77636 hydrochloride

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1701/10
1701/50
A 77636 hydrochloride | CAS No. 145307-34-2 | Dopamine D1 and D5 Receptor Agonists
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Description: Potent and selective D1-like agonist; orally active

Chemical Name: (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity

A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. Exhibits 11-fold cell type bias over dopamine in a functional assay in U2 cells.

Technical Data

M.Wt:
365.9
Formula:
C20H27NO3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
145307-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A 77636 hydrochloride

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