Potent and selective dopamine D1
-like receptor agonist (pEC50
values are 8.97 and < 5 for D1
-like and D2
-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo
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The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat.
Acquas et al.
A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.
Kebabian et al.
Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
Lewis et al.
The citations listed below are publications that use Tocris products. Selected citations for A 77636 hydrochloride include:
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