Potent histamine H4
receptor antagonist (pKi
values are 8.24 and 8.47 in human and rat H4
receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3
receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo
= 42 μ
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All Tocris products are intended for laboratory research use only.
Molecular and biochemical pharmacology of the histamine H4 receptor.
Leurs et al.
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Liu et al.