ABT 724 trihydrochloride

Catalog # Availability Size / Price Qty
ABT 724 trihydrochloride | CAS No. 587870-77-7 | Dopamine D4 Receptor Agonists
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Description: Potent and selective D4 partial agonist; proerectile

Chemical Name: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride

Purity: ≥99%

Product Details

Biological Activity

ABT 724 trihydrochloride is an ABT 724 is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine), which displays no agonist activity at D2 receptors (EC50 > 10 μM). ABT 724 is selective in rats in vivo and produces penile erection following i.c.v. administration, and increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. This compound displays minimal side effects.

External Portal information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of ABT 724 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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