ABT 724 trihydrochloride

Key Product Details

Product Description

ABT 724 trihydrochloride is an ABT 724 is a potent dopamine D₄ receptor partial agonist (EC₅₀ = 12.4 nM; 61% efficacy vs. dopamine), which displays no agonist activity at D₂ receptors (EC₅₀ > 10 μM). ABT 724 is selective in rats in vivo and produces penile erection following i.c.v. administration, and increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. This compound displays minimal side effects.

External Portal information

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of ABT 724 is reviewed on the chemical probes website.

Product Specifications for ABT 724 trihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ABT 724 trihydrochloride

The following data is based on the product molecular weight 402.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.83 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cowart Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a DArgic agent with a novel mode of action for the potential treatment of erectile dysfunction. J.Med.Chem. 2004 PMID: 15239663
• Brioni Activation of DA D₄ receptors by ABT-724 induces penile erection in rats. Proc.Natl.Acad.Sci.USA
• Stewart DA D₄ ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J.Med.Chem. 2004 PMID: 15084133

Product Documents for ABT 724 trihydrochloride