Ac2-12

Name: Ac2-12
Brand: Tocris Bioscience
SKU: 1846

Tocris Bioscience | Catalog # 1846

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Product Documents

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Discontinued Product

1846 has been discontinued. View all Cell Adhesion Inhibitors products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

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Product Description

Ac2-12 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Product Specifications for Ac2-12

Molecular Weight

1351.58

Formula

C₆₃H₉₄N₁₄O₁₇S

Storage

Desiccate at -20°C

CAS Number

256447-08-2

PubChem ID

90488718

InChI Key

SUDAISORCUBKHK-RCVXMRHOSA-N

SMILES

CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% acetonitrile / water

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Background References

References are publications that support the biological activity of the product.

Perretti Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 2001 PMID: 11395373
Lim Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9826735

Product Documents for Ac2-12

Certificate of Analysis

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Product Specific Notices for Ac2-12

For research use only

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