Ac2-12 (CAS 256447-08-2): R&D Systems
Catalog Number: 1846
Biological Activity
Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
Technical Data
  • M.Wt:
    1351.58
  • Formula:
    C63H94N14O17S
  • Sequence:
    AMVSEFLKQAW

    (Modifications: Ala-1 = N-terminal Ac)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    256447-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The William Harvey Research Institute
Background References
  1. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1
    Lim et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535
  2. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics.
    Perretti et al.
    Am.J.Pathol., 2001;158:1969

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