Catalog Number: 2728
Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Biological Activity
Potent and selective GluR5-containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.
Technical Data
  • M.Wt:
    429.45
  • Formula:
    C20H19N3O6S
  • Solubility:
    Soluble to 20 mM in 3eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    936095-50-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis
    Dolman et al.
    J.Med.Chem., 2007;50:1558
  2. ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function.
    Dargan et al.
    Neuropharmacology, 2009;56:121
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ACET include:

1 Citations: Showing 1 - 1

  1. LTD expression is independent of glutamate receptor subtype.
    Authors: Granger and Nicoll
    J Virol 2014;6:15

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