Potent and selective GluR5-containing kainate receptor antagonist (IC50
= 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro
at nanomolar concentrations.
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Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis
Dolman et al.
ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function.
Dargan et al.
The citations listed below are publications that use Tocris products. Selected citations for ACET include:
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