ACET

Key Product Details

Product Description

ACET is a potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC₅₀ = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for ACET

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ACET

The following data is based on the product molecular weight 429.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.64 mL	58.21 mL	116.43 mL
1 mM	2.33 mL	11.64 mL	23.29 mL
2 mM	1.16 mL	5.82 mL	11.64 mL
10 mM	0.23 mL	1.16 mL	2.33 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 43 publications citing the usage of this product.

• Dargan ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 2009 PMID: 18789344
• Dolman Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis J.Med.Chem. 2007 PMID: 17348638

Product Documents for ACET