Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50
= 0.7 μ
M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1
growth arrest selectively in transformed cells (IC50
values are 6.4 and 9.4 μ
M in HPV16-immortalized and normal keratinocytes respectively).
Soluble to 30 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.
Ben-Bassat et al.
Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.
Tyrosine kinase inhibition: an approach to drug development.
Levitzki and Gazit