AG 555

Key Product Details

Product Description

AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G₁ growth arrest selectively in transformed cells (IC₅₀ values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

Product Specifications for AG 555

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AG 555

The following data is based on the product molecular weight 322.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	10.34 mL	51.70 mL	103.40 mL
1.5 mM	2.07 mL	10.34 mL	20.68 mL
3 mM	1.03 mL	5.17 mL	10.34 mL
15 mM	0.21 mL	1.03 mL	2.07 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gazit Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 1991 PMID: 1676428
• Levitzki and Gazit Tyrosine kinase inhibition: an approach to drug development. Science 1995 PMID: 7892601
• Ben-Bassat Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 1999 PMID: 10454524

Product Documents for AG 555