AGN 192403 hydrochloride

Biological Activity

AGN 192403 hydrochloride is an i₁ imidazoline binding site selective ligand with a potency at I₁ comparable to moxonidine, but devoid of affinity for adrenoceptors and the I₂ binding site. Causes none of the physiological responses associated with the I₁ binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts.
   Mukaddam-Daher et al.
   Eur.J.Pharmacol., 2006;541:73
2. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
   Raasch et al.
   Br.J.Pharmacol., 2002;135:663
3. Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline₁ receptor specific agent.
   Munk et al.
   J.Med.Chem., 1996;39:1193
4. Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy.
   Dvela-Levitt
   Cell, 2019;178:521

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