Catalog Number: 1072
Chemical Name: (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Biological Activity
I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Interestingly, in animal models, this compound causes none of the physiological responses associated with the I1 binding site.
Technical Data
  • M.Wt:
    189.73
  • Formula:
    C10H19N.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    1021868-90-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.
    Munk et al.
    J.Med.Chem., 1996;39:1193
  2. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
    Raasch et al.
    Br.J.Pharmacol., 2002;135:663
  3. Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts.
    Mukaddam-Daher et al.
    Eur.J.Pharmacol., 2006;541:73
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Authors: Sánchez-Blázquez Et al.
    Br J Pharmacol 2000;130:146

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