ANA 12

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ANA 12 | CAS No. 219766-25-3 | Trk Receptor Antagonists
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Description: TrkB receptor antagonist

Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide

Product Details
Citations (9)
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Reviews

Biological Activity

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

Technical Data

Formula:
C22H21N3O3S
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
219766-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ANA 12

The citations listed below are publications that use Tocris products. Selected citations for ANA 12 include:

9 Citations: Showing 1 - 9

  1. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
    Authors: Zhou Et al.
    Cell Rep  2019;27:3844
  2. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
    Authors: Livingstone Et al.
    Front Mol Neurosci  2019;12:198
  3. 7,8,3'-Trihydroxyflavone ameliorate oxidative stress in vivo and promotes neurite regeneration in vitro in rat retinal ganglion cells.
    Authors: Han Et al.
    Eur.J.Pharmacol.  2018;823:283
  4. The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor.
    Authors: O'Neill Et al.
    Front Cell Neurosci  2018;12:60
  5. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
    Authors: Hashimotodani Et al.
    Neuron  2017;95:928
  6. Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
    Authors: Fischer Et al.
    J Neurosci  2017;37:6786
  7. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  8. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  9. High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.
    Authors: Stepan Et al.
    Front Neural Circuits  2015;9:70

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