TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50
values are 45.6 nM and 41.1 μ
M for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties.
Soluble to 50 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.
Cazorla et al.
The citations listed below are publications that use Tocris products. Selected citations for ANA 12 include:
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