Inhibitor of NF-κ
B signaling; also attenuates concanavaline-induced IFNγ
production in murine T cells (IC50
= 1.7 μ
M). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
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Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.
Guan et al.
Br.J.Pharmacol. [Epub ahead of print], 2012;
Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer.
Liu et al.
Genes Cancer., 2011;2:151
Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.
Burgos et al.