Chemical Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Biological ActivityInhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.
Guan et al.
Br.J.Pharmacol. [Epub ahead of print], 2012;
Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer.
Liu et al.
Genes Cancer., 2011;2:151
Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.
Burgos et al.
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