Andrographolide

Key Product Details

Product Description

Andrographolide is an inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC₅₀ = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.

Product Specifications for Andrographolide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Andrographolide

The following data is based on the product molecular weight 350.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.53 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Burgos Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 2005 PMID: 15931581
• Guan Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] 2012 PMID: 23146110
• Liu Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2011 PMID: 21779488

Product Documents for Andrographolide