Chemical Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Biological ActivityInhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.
Guan et al.
Br.J.Pharmacol. [Epub ahead of print], 2012;
Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer.
Liu et al.
Genes Cancer., 2011;2:151
Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.
Burgos et al.
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