Catalog Number: 2511
Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Biological Activity
Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.
Technical Data
  • M.Wt:
    440.5
  • Formula:
    C22H28N6O4
  • Sequence:
    N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
  • Solubility:
    Soluble to 5 mg/ml in 20% ethanol / water
  • Storage:
    Store at -20°C
  • CAS No:
    158921-85-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase.
    He et al.
    J.Pharmacol.Exp.Ther., 1998;286:289
  2. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi.
    Barrios et al.
    Life Sci., 1998;63:2295
  3. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release.
    He et al.
    J.Pharmacol.Exp.Ther., 2004;309:119
  4. Tryptase inhibitors: a novel class of anti-inflammatory drugs.
    Numerof et al.
    Exp.Opin.Invest.Drugs., 1997;6:811
Citations:

The citations listed below are publications that use Tocris products. Selected citations for APC 366 include:

1 Citations: Showing 1 - 1

  1. Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury.
    Authors: Matsuda Et al.
    Am J Transl Res 2015;2015:635041

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