APC 366

Tocris Bioscience | Catalog # 2511

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Citations (13)

Product Documents

Tryptase inhibitor

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Tryptase inhibitor

View all Protease-Activated Receptor Inhibitors »

Product Description

APC 366 is a selective inhibitor of mast cell tryptase (K_i = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Product Specifications for APC 366

Molecular Weight

440.50

Formula

C₂₂H₂₈N₆O₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

CAS Number

158921-85-8

PubChem ID

177340

InChI Key

SKYWIMYOGAWOMB-IRXDYDNUSA-N

SMILES

OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 5mg/ml in 20% ethanol / water

Calculators

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Mass

Concentration

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g/mol

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Numerof Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs.
Barrios Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998 PMID: 9877219
He Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 2004 PMID: 14722328
He A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 1998 PMID: 9655871

Product Documents for APC 366

Certificate of Analysis

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Download SDS

Product Specific Notices for APC 366

For research use only

Citations for APC 366

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