Selective inhibitor of mast cell tryptase (Ki
= 7.1 μ
M) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo
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A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase.
He et al.
Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi.
Barrios et al.
Life Sci., 1998;63:2295
Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release.
He et al.
Tryptase inhibitors: a novel class of anti-inflammatory drugs.
Numerof et al.
The citations listed below are publications that use Tocris products. Selected citations for APC 366 include:
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