APC 366

Catalog # Availability Size / Price Qty
2511/5
APC 366
1 Image
Description: Tryptase inhibitor

Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

Product Details
Citations (1)
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Biological Activity

Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

M.Wt:
440.5
Formula:
C22H28N6O4
Sequence:
N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Solubility:
Soluble to 5 mg/ml in 20% ethanol / water
Storage:
Store at -20°C
CAS No:
158921-85-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase.
    He et al.
    J.Pharmacol.Exp.Ther., 1998;286:289
  2. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi.
    Barrios et al.
    Life Sci., 1998;63:2295
  3. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release.
    He et al.
    J.Pharmacol.Exp.Ther., 2004;309:119
  4. Tryptase inhibitors: a novel class of anti-inflammatory drugs.
    Numerof et al.
    Exp.Opin.Invest.Drugs., 1997;6:811

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Citation for APC 366

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