APC 366

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APC 366
1 Image
Description: Tryptase inhibitor

Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

Product Details

Biological Activity

APC 366 is a selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

Soluble to 5 mg/ml in 20% ethanol / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase.
    He et al.
    J.Pharmacol.Exp.Ther., 1998;286:289
  2. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi.
    Barrios et al.
    Life Sci., 1998;63:2295
  3. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release.
    He et al.
    J.Pharmacol.Exp.Ther., 2004;309:119
  4. Tryptase inhibitors: a novel class of anti-inflammatory drugs.
    Numerof et al.
    Exp.Opin.Invest.Drugs., 1997;6:811

Product Datasheets

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