Aprepitant

Catalog # Availability Size / Price Qty
6486/50
Cat.No. 6486 - Aprepitant | C23H21F7N4O3 | CAS No. 170729-80-3
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Description: Potent long-acting hNK-1 antagonist

Chemical Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

Purity: ≥99%

Product Details
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Biological Activity

Potent long-acting hNK-1 antagonist, (IC50 = 0.09 nM and Kd = 19 pM). Inhibits induced foot-tapping in gerbils. CNS penetrant and orally bioavailable. Antiemetic.

Technical Data

M.Wt:
534.43
Formula:
C23H21F7N4O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
170729-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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