AR-C 141990 hydrochloride

Key Product Details

Product Description

AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pK_i = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

Product Specifications for AR-C 141990 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AR-C 141990 hydrochloride

The following data is based on the product molecular weight 529.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.89 mL	9.45 mL	18.90 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
10 mM	0.19 mL	0.95 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Thiesen In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 2015 PMID: 25986445
• Påhlman Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 2012 PMID: 23137339

Product Documents for AR-C 141990 hydrochloride