Monocarboxylate transporter (MCT1) inhibitor (pKi
= 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.
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All Tocris products are intended for laboratory research use only.
Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1.
Påhlman et al.
In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1.
Thiesen et al.