Potent inhibitor of cdk4/cyclin D1 (IC50
= 59 nM). Also active against CaM kinase II (IC50
= 25 nM) but displays selectivity over several other kinases in vitro
values for inhibition of PKA and PKC are > 2 and > 100 μ
M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro
= 200 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication.
Slater et al.
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.
Zhu et al.
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Sanchez-Martinez et al.