Chemical Name: 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Biological ActivityARN 726 is a potent N-acylethanolamine acid amidase (NAAA) inhibitor (IC50 values are 27 nM and 63 nM for human and rat NAAA, respectively). Displays anti-inflammatory effects in human macrophages ex vivo and mouse models of lung inflammation and arthritis. Also used as NAAA activity-based protein profiling (ABPP) probe to detect NAAA in cell lysates or intact cells.
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A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation.
Ribeiro et al.
ACS Chem.Biol., 2015;10:1838
Activity-based probe for N-acylethanolamine acid amidase.
Romeo et al.
ACS Chem.Biol., 2015;10:2057
An important role for N-acylethanolamine acid amidase in the complete freund's adjuvant rat model of arthritis.
Bonezzi et al.
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