Arvanil

Name: Arvanil
Brand: Tocris Bioscience
SKU: 1354

Tocris Bioscience | Catalog # 1354

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Product Documents

Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist

Discontinued Product

1354 has been discontinued. View all Cannabinoid R1/CB1 Agonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist

View all Cannabinoid R1/CB1 Agonists »

Product Description

Arvanil is a cannabinoid CB₁ and vanilloid TRPV1 (VR1) agonist (K_i values are 0.5 and 0.3 μM respectively). Also inhibits the anandamide transporter (IC₅₀ = 3.6 μM). Analgesic, vasodilatory and anti-inflammatory in vivo.

Product Specifications for Arvanil

Molecular Weight

439.64

Formula

C₂₈H₄₁NO₃

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide

CAS Number

128007-31-8

PubChem ID

6449767

InChI Key

QVLMCRFQGHWOPM-ZKWNWVNESA-N

SMILES

O=C(NCC1=CC=C(O)C(OC)=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Calculators

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Background References

References are publications that support the biological activity of the product.

Melck Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors. Biochem.Biophys.Res.Commun. 1999 PMID: 10448105
Szallasi and Di Marzo New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 2000 PMID: 11006466
Di Marzo Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. Eur.J.Pharmacol. 2000 PMID: 11040343

Product Documents for Arvanil

Certificate of Analysis

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Product Specific Notices for Arvanil

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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