and vanilloid TRPV1 (VR1) agonist (Ki
values are 0.5 and 0.3 μ
M respectively). Also inhibits the anandamide transporter (IC50
= 3.6 μ
M). Analgesic, vasodilatory and anti-inflammatory in vivo
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Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide.
Di Marzo et al.
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors.
Melck et al.
New perspectives on enigmatic vanilloid receptors.
Szallasi and Di Marzo
Trends Neurosci., 2000;23:491