AZ 12216052

Catalog # Availability Size / Price Qty
4832/10
4832/50
Cat.No. 4832 - AZ 12216052 | C19H22BrNOS | CAS No. 1290628-31-7
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Description: Positive allosteric modulator of mGlu8

Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide

Purity: ≥98%

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Biological Activity

Positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.

Technical Data

M.Wt:
392.35
Formula:
C19H22BrNOS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1290628-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges.
    Duvoisin et al.
    Behav.Brain Res., 2011;221:50
  2. Acute pharmacological modulation of mGluR8 reduces measures of anxiety.
    Duvoisin et al.
    Behav.Brain Res., 2010;212:168
  3. Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity.
    Chruscicka et al.
    Pharmacol.Rep., 2013;65:38

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