AZ 12216052

Key Product Details

Product Description

AZ 12216052 is a positive allosteric modulator at mGlu₈ receptors. Exhibits anxiolytic effects in mouse models of anxiety.

Product Specifications for AZ 12216052

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZ 12216052

The following data is based on the product molecular weight 392.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Duvoisin Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 2011 PMID: 21382421
• Duvoisin Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 2010 PMID: 20385173
• Chruscicka Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep.

Product Documents for AZ 12216052