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Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors
Selective positive allosteric modulator of mGlu4 receptors
Positive allosteric modulator of mGlu4 receptors
Potent and selective positive allosteric modulator of mGlu4 receptors
Positive allosteric modulator of mGlu4 receptors
Positive allosteric modulator of mGlu4 receptors
Positive allosteric modulator of mGlu8 receptors
Selective positive allosteric modulator of group III mGlu receptors
Negative allosteric modulator of mGlu7 receptors; brain penetrant
Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant