Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50
= 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes only under agreement from AstraZeneca UK Ltd.
Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.
Hewitt et al.
J.Cell Biol., 2010;190:25
A chemical tool box defines mitotic and interphase roles for Mps1 kinase.
Lan and Cleveland
Mps1 directs the assembly of Cdc20 inhbitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
Maciejowski et al.
J.Cell Biol., 2010;190:89
The citations listed below are publications that use Tocris products. Selected citations for AZ 3146 include:
Showing Results 1 - 2 of 2