AZ 3146

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3994/10
3994/50
AZ 3146 | CAS No. 1124329-14-1 | TTK/Mps1 Kinase Inhibitors
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Description: Potent and selective Mps1 kinase inhibitor

Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Purity: ≥99%

Product Details
Citations (8)
Reviews

Biological Activity

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Technical Data

M.Wt:
452.55
Formula:
C24H32N6O3
Solubility:
Soluble to 25 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1124329-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca UK Ltd.

Product Datasheets

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Citations for AZ 3146

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8 Citations: Showing 1 - 8

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