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AZ 3146

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AZ 3146 | CAS No. 1124329-14-1 | TTK/Mps1 Kinase Inhibitors
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Description: Potent and selective Mps1 kinase inhibitor

Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Purity: ≥99%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Technical Data

M.Wt:
452.55
Formula:
C24H32N6O3
Solubility:
Soluble to 25 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1124329-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca UK Ltd.

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Citations for AZ 3146

The citations listed below are publications that use Tocris products. Selected citations for AZ 3146 include:

8 Citations: Showing 1 - 8

  1. Oncogenic MYC amplifies mitotic perturbations.
    Authors: Littler Et al.
    Open Biol  2019;9:190136
  2. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.
    Authors: McKinley Et al.
    Elife  2018;7
  3. Chromosome Segregation Is Biased by Kinetochore Size.
    Authors: Drpic Et al.
    Curr Biol  2018;28:1344
  4. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.
    Authors: Karki
    Nat Commun  2017;8:15803
  5. Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment.
    Authors: Haase Et al.
    Dev Cell  2017;42:640
  6. Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.
    Authors: Garvanska Et al.
    Biol Open  2016;5:1441
  7. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy.
    Authors: Bennett Et al.
    Toxins (Basel)  2015;6:20921
  8. Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation.
    Authors: Hermant Et al.
    PLoS One  2013;8:e57461

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