Potent inhibitor of NF-κ
B activation (IC50
= 85 nM); decreases Iκ
phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α
, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.
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All Tocris products are intended for laboratory research use only.
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Hu et al.
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
Johnson et al.
Synthesis and antitumor activity of ester-modified analogues of bengamide B.
Kinder et al.