Catalog Number: 5273
Chemical Name: (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide
Biological Activity
Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 1 mg/ml in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
    Hu et al.
    Chem.Biol., 2007;14:764
  2. Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
    Johnson et al.
    Bioorg.Med.Chem., 2012;20:4348
  3. Synthesis and antitumor activity of ester-modified analogues of bengamide B.
    Kinder et al.
    J.Med.Chem., 2001;44:3692

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