Chemical Name: 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
Biological ActivityBF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.
MacLeod et al.
ACS Med.Chem.Lett., 2013;4:585
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III.
van der Schaar et al.
Antimicrob.Agents Chemother., 2013;57:4971
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