BIBX 1382 dihydrochloride
Chemical Name: N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride
Biological ActivityBIBX 1382 dihydrochloride is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives.
Solca et al.
Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration.
Dittrich et al.
Citation for BIBX 1382 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BIBX 1382 dihydrochloride include:
1 Citation: Showing 1 - 1
Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther 2013;14:638
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VersaClone cDNA Plasmids
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Used in vitro to investigate ERG pathways