BIBX 1382 dihydrochloride

Catalog # Availability Size / Price Qty
2416/10
2416/1
BIBX 1382 dihydrochloride | CAS No. 1216920-18-1 | EGF Receptor Inhibitors
1 Image
Description: Highly selective EGFR-kinase inhibitor

Chemical Name: N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride

Purity: ≥97%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.

Technical Data

M.Wt:
460.77
Formula:
C18H19ClFN7.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
1216920-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for BIBX 1382 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BIBX 1382 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther  2013;14:638

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for BIBX 1382 dihydrochloride

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used BIBX 1382 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


In vitro culture
By Anonymous on 08/05/2018
Species: Mouse

Used in vitro to investigate ERG pathways


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.