BIBX 1382 dihydrochloride

Tocris Bioscience | Catalog # 2416

Highly selective EGFR-kinase inhibitor
Tocris Bioscience
Discontinued Product
2416 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description

Highly selective EGFR-kinase inhibitor
View all EGF Receptor Inhibitors »

Product Description

BIBX 1382 dihydrochloride is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.

Product Specifications for BIBX 1382 dihydrochloride

Molecular Weight

460.77

Formula

C18H19ClFN7.2HCl

Storage

Desiccate at +4°C

Purity

≥97% (HPLC)

Chemical Name

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride

CAS Number

1216920-18-1

PubChem ID

46861540

InChI Key

RFXGEKWBTCMDAW-UHFFFAOYSA-N

SMILES

Cl.Cl.CN1CCC(CC1)NC1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.39 50
DMSO 19.39 50

Preparing Stock Solutions for BIBX 1382 dihydrochloride

The following data is based on the product molecular weight 460.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.34 mL 21.70 mL 43.41 mL
2.5 mM 0.87 mL 4.34 mL 8.68 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
25 mM 0.09 mL 0.43 mL 0.87 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for BIBX 1382 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIBX 1382 dihydrochloride

For research use only

Citations for BIBX 1382 dihydrochloride

Customer Reviews for BIBX 1382 dihydrochloride (2)

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  • Blockage of EGFR signaling
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    BIBX 1382 dihydrochloride was used to block EGFR signaling and determine the pathway of a chemotherapeutic in glioblastoma lines. The inhibitor worked nicely, and the results were consistent.
  • In vitro culture
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 08/05/2018
    Used in vitro to investigate ERG pathways

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