BIBX 1382 dihydrochloride
Chemical Name: N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride
Purity: ≥97%
Biological Activity
BIBX 1382 dihydrochloride is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives.
Solca et al.
J.Pharmacol.Exp.Ther., 2004;311:502 -
Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration.
Dittrich et al.
Eur.J.Cancer, 2002;38:1072
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Citation for BIBX 1382 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BIBX 1382 dihydrochloride include:
1 Citation: Showing 1 - 1
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Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther 2013;14:638
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Used in vitro to investigate ERG pathways
