Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
Biological ActivityNeutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Gehin et al.
Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
Schoenermark et al.
Citations for BMS 195614
The citations listed below are publications that use Tocris products. Selected citations for BMS 195614 include:
5 Citations: Showing 1 - 5
RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta.
Authors: Flamini Et al.
J Cell Mol Med 2014;18:1113
Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.
Authors: Liang Et al.
Invest Ophthalmol Vis Sci 2013;54:3493
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.
Authors: Chen Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for BMS 195614
There are currently no reviews for this product. Be the first to review BMS 195614 and earn rewards!
Have you used BMS 195614?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image