Catalog Number: 3660
Alternate Names: BMS614
Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
Biological Activity
Neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
Technical Data
  • M.Wt:
    448.51
  • Formula:
    C29H24N2O3
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    253310-42-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
    Gehin et al.
    Chem.Biol., 1999;6:519
  2. Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
    Germain et al.
    Chem.Biol., 2009;16:479
  3. Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
    Schoenermark et al.
    Ann.N.Y.Acad.Sci., 1999;30:878
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BMS 195614 include:

2 Citations: Showing 1 - 2
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  1. Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta.
    Authors: Flamini Et al.
    J Cell Mol Med 2014;18:1113
  2. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun 2013;4:2175

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