BMS 195614

Catalog # Availability Size / Price Qty
3660/10
3660/50
BMS 195614 | CAS No. 182135-66-6 | Retinoic Acid Receptor Antagonists
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Description: Selective RARα antagonist
Alternative Names: BMS614

Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid

Purity: ≥98%

Product Details
Citations (5)
Reviews

Biological Activity

Neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Technical Data

M.Wt:
448.51
Formula:
C29H24N2O3
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
182135-66-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
    Gehin et al.
    Chem.Biol., 1999;6:519
  2. Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
    Germain et al.
    Chem.Biol., 2009;16:479
  3. Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
    Schoenermark et al.
    Ann.N.Y.Acad.Sci., 1999;30:878

Product Datasheets

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Citations for BMS 195614

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5 Citations: Showing 1 - 5

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