Neutral retinoic acid receptor (RAR) α
-selective antagonist (Ki
= 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
Soluble to 25 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Gehin et al.
Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
Schoenermark et al.
The citations listed below are publications that use Tocris products. Selected citations for BMS 195614 include:
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