Chemical Name: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
Biological ActivityBMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Gehin et al.
Differential action on coregulator interaction defines retinoid agonists and neutral antagonists.
Germain et al.
Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
Schoenermark et al.
Citations for BMS 195614
The citations listed below are publications that use Tocris products. Selected citations for BMS 195614 include:
5 Citations: Showing 1 - 5
RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta.
Authors: Flamini Et al.
J Cell Mol Med 2014;18:1113
Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis.
Authors: Liang Et al.
Invest Ophthalmol Vis Sci 2013;54:3493
Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
Authors: Johansson Et al.
Nat Commun 2013;4:2175
A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.
Authors: Chen Et al.
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