BMS 195614

Key Product Details

Product Description

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (K_i = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Product Specifications for BMS 195614

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 195614

The following data is based on the product molecular weight 448.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.92 mL	44.59 mL	89.18 mL
1.25 mM	1.78 mL	8.92 mL	17.84 mL
2.5 mM	0.89 mL	4.46 mL	8.92 mL
12.5 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Germain Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 2009 PMID: 19477412
• Schoenermark Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci.
• Gehin Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 1999 PMID: 10421757

Product Documents for BMS 195614