Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Biological ActivityBRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inducers of Ins expression in pancreatic alpha cells.
Fomina-Yadlin et al.
Proc.Natl.Acad.Sci. USA, 2010;107:15099
Citation for BRD 7389
The citations listed below are publications that use Tocris products. Selected citations for BRD 7389 include:
1 Citation: Showing 1 - 1
EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.
Authors: Breindel Et al.
Cancer Res 2013;73:5053
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