Home / RSK Inhibitors / BRD 7389

BRD 7389

Catalog #: 4037
3 Citations Datasheet / COA / SDS

Discontinued Product

4037 has been discontinued.
View all RSK Inhibitors products.
BRD 7389 | CAS No. 376382-11-5 | RSK Inhibitors
1 Image
Description: Ribosomal S6 kinase inhibitor

Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

Purity: ≥97%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.

Technical Data

M.Wt:
366.41
Formula:
C24H18N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
376382-11-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Phosphorylation of the chromatin binding domain of KSHV LANA.
    Woodard, Crystal, Shamay, Meir, Liao, Gangling, Zhu, Jian, Ng, Ai Na, Li, Renfeng, Newman, Rob, Rho, Hee-Sool, Hu, Jianfei, Wan, Jun, Qian, Jiang, Zhu, Heng, Hayward, S Diane
    PLoS Pathog, 2012;8(10):e1002972.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for BRD 7389

The citations listed below are publications that use Tocris products. Selected citations for BRD 7389 include:

3 Citations: Showing 1 - 3

  1. Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.
    Authors: James B Et al.
    Nat Immunol  2020;21:857-867
  2. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.
    Authors: Davide Et al.
    Cancer Cell  2018;33:91-107.e6
  3. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.
    Authors: Breindel Et al.
    Cancer Res  2013;73:5053

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BRD 7389

There are currently no reviews for this product. Be the first to review BRD 7389 and earn rewards!

Have you used BRD 7389?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.