Bretazenil

Catalog # Availability Size / Price Qty
3568/10
Bretazenil | CAS No. 84379-13-5 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine partial agonist
Alternative Names: Ro 16-6028

Chemical Name: (13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester

Purity: ≥98%

Product Details
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Biological Activity

Partial agonist at the GABAA benzodiazepine site (EC50 = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.

Technical Data

M.Wt:
418.28
Formula:
C19H20BrN3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
84379-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil.
    Rundfeldt et al.
    J.Pharmacol.Exp.Ther., 1995;275:693
  2. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i
    Munro et al.
    J.Pharmacol.Exp.Ther., 2008;327:969
  3. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor.
    Puia et al.
    Proc.Natl.Acad.Sci. USA Neurobiology, 1992;89:3620

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