Bretazenil

Key Product Details

Product Description

Bretazenil is a partial agonist at the GABA_A benzodiazepine site (EC₅₀ = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.

Product Specifications for Bretazenil

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Bretazenil

The following data is based on the product molecular weight 418.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.91 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Munro Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i J.Pharmacol.Exp.Ther. 2008 PMID: 18791060
• Puia Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology
• Rundfeldt Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 1995 PMID: 7473156

Product Documents for Bretazenil