Chemical Name: (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
Biological ActivityBudesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease.
Spencer et al.
Modulation by budes. of DNA methylation and mRNA expression in mouse lung tumors.
Pereira et al.
Chemoprevention of pulmonary carcinogenesis by aerosolized budes. in female A/J mice.
Wattenberg et al.
Cancer Res., 2007;57:5489
Citations for Budesonide
The citations listed below are publications that use Tocris products. Selected citations for Budesonide include:
3 Citations: Showing 1 - 3
β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
Scientific Reports 2017;7:39905
Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.
Authors: Kim Et al.
Front Endocrinol (Lausanne) 2016;NULL:me20161029
A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells.
Authors: Liu Et al.
Mol Endocrinol 2015;11:4121
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