Catalog Number: 4200
Chemical Name: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Biological Activity
Selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Selective against six other histone acetyltransferases (HATs). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This compound is a mixture of Z:E isomers (~ 80:20)
Background References
  1. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
    Bowers et al.
    Chem.Biol., 2010;17:471
  2. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
    Mali et al.
    Stem Cells, 2010;28:713
  3. HAT trick: p300, small molecule, inhibitor.
    Ott and Verdi
    Chem.Biol., 2010;17:417
  4. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
    Crump et al.
    Proc.Natl.Acad.Sci. USA, 2011;108:7814
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