Selective p300/CREB-binding protein (CBP) inhibitor (Ki
= 400 nM). Selective against six other histone acetyltransferases (HATs). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.
Soluble to 25 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- This compound is a mixture of Z:E isomers (~ 80:20)
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Bowers et al.
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
Mali et al.
Stem Cells, 2010;28:713
HAT trick: p300, small molecule, inhibitor.
Ott and Verdi
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
Crump et al.
Proc.Natl.Acad.Sci. USA, 2011;108:7814