Chemical Name: 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Biological ActivityTNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.
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A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.
Ma et al.
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VersaClone cDNA Plasmids
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Used in Fibroblast cytotoxicity assay