Cytokine Compounds: Products

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Antifibrotic agent; regulates cytokine levels in vivo

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Binds cereblon; also TNF-α synthesis inhibitor

Reported macrophage migration inhibitory factor (MIF) inhibitor

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF

Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

Selective Syk kinase inhibitor

Immunomodulator; reduces production of pro-inflammatory cytokines

Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

MIF binder

Macrophage migration inhibitory factor (MIF) inhibitor

Immunomodulatory and antitumor compound

Stimulated by IFN-γ; marker of immune activation

Suppressor of MDK expression; inhibits PI 3-K signaling

Active metabolite binds CPSF3; Pro-drug

Potent and selective IRAK4 inhibitor

TNF-α inhibitor

gp130 agonist; brain penetrant and neuroprotectant

NLRP3 inflammasome inhibitor

TIR-TIR interaction inhibitor

gp130 modulator; activates JAK/STAT signaling

Inhibitor of pro-inflammatory mediator release from mast cells

TRAF6-Ubc13 interaction inhibitor