cAC 253

   
Product Datasheet
Catalog Number:6549
Chemical Name:
Product Details
Reviews
Biological Activity
Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
Technical Data
  • M.Wt:
    3009.36
  • Formula:
    C126H202N42O40S2
  • Sequence:
    CLGRLSQELHRLQTYPRTNTGSNTYC

    (Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the University of Alberta, US patent 2,967,616, Canadian patent 15/705,789.
Product Datasheets

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