Home / Calcitonin and Related Receptor Antagonists / cAC 253

cAC 253

Catalog #: 6549 Datasheet / COA / SDS

Discontinued Product

6549 has been discontinued.
View all Calcitonin and Related Receptor Antagonists products.
cAC 253
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Description: Amylin (AMY3) antagonist; brain penetrant
Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

cAC 253 is an amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.

Technical Data

M.Wt:
3009.36
Formula:
C126H202N42O40S2
Sequence:
CLGRLSQELHRLQTYPRTNTGSNTYC

(Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Alberta, US patent 2,967,616, Canadian patent 15/705,789.

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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