Biological ActivityAmylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
(Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.
Soudy et al.
Alzheimers Dement. (N Y), 201;3:44
Amylin in Alzheimer's disease: Pathological peptide or potential treatment?
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