cAC 253

Catalog # Availability Size / Price Qty
6549/500U
Cat.No. 6549 - cAC 253 | Cys-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-Cys-NH2 (Disulfide bridge: 1 - 26)
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Description: Amylin (AMY3) receptor antagonist; brain penetrant
Product Details
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Biological Activity

Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.

Technical Data

M.Wt:
3009.36
Formula:
C126H202N42O40S2
Sequence:
CLGRLSQELHRLQTYPRTNTGSNTYC

(Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from the University of Alberta, US patent 2,967,616, Canadian patent 15/705,789.

Product Datasheets

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