Biological ActivityAmylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
(Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.
Soudy et al.
Alzheimers Dement. (N Y), 201;3:44
Amylin in Alzheimer's disease: Pathological peptide or potential treatment?
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