Catalog Number: 2700
Alternate Names: MC 903
Chemical Name: (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
Biological Activity
Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
Technical Data
  • M.Wt:
    412.6
  • Formula:
    C27H40O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    112965-21-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo.
    Binderu
    Pharmacol.Toxicol., 1993;72:240
  2. Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats.
    Knutson et al.
    Biochem.Pharmacol., 1997;53:829
  3. Antitumor properties of diastereomeric and geometric analogs of vitamin D3.
    Wietrzyk et al.
    Anticancer Drugs, 2007;18:447
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calcipotriol include:

1 Citations: Showing 1 - 1

  1. TSLP is differentially regulated by vitamin D3 and cytokines in human skin.
    Authors: Landheer Et al.
    Dev Biol 2015;3:32

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