Calcipotriol

Tocris Bioscience | Catalog # 2700

Vitamin D3 analog
Tocris Bioscience

Key Product Details

Description

Vitamin D3 analog

Alternative Names

MC 903
View all Additional VDR-like Receptor Compounds »

Product Description

Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

Product Specifications for Calcipotriol

Molecular Weight

412.60

Formula

C27H40O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol

CAS Number

112965-21-6

PubChem ID

5288783

InChI Key

LWQQLNNNIPYSNX-UROSTWAQSA-N

SMILES

[H][C@@]12[C@]([C@]([C@@H](/C=C/[C@@H](O)C4CC4)C)([H])CC2)(C)CCC/C1=C\C=C3/C([C@@H](O)C[C@H](O)C3)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.26 100
Ethanol 41.26 100

Preparing Stock Solutions for Calcipotriol

The following data is based on the product molecular weight 412.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Product Documents for Calcipotriol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Calcipotriol

For research use only

Customer Reviews for Calcipotriol (3)

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  • Atopic dermatitis
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 06/15/2024
    Using it to induce atopic dermatitis animal model.
  • Working well
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 09/20/2022
    induce atopic dermatitis on ear and back skin
  • MC903 treatment and pathology assessment
    Name: Jing Feng
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/10/2018
    MC903 was used to induce an Atopical Dermatitis-like inflammation and itch
    Calcipotriol 2700

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