Catalog Number: 2561
Alternate Names: R 24571
Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
Biological Activity
Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
Technical Data
  • M.Wt:
    687.7
  • Formula:
    C31H23Cl7N2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    57265-65-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.
    Gietzen
    Biochem.J., 1983;216:611
  2. Effect of calmidazolium analogs on calcium influx in HL-60 cells.
    Harper and Daly
    Biochem.Pharmacol., 2000;60:317
  3. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells.
    Peppiatt et al.
    Biochem.J., 2004;381:929
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calmidazolium chloride include:

1 Citations: Showing 1 - 1

  1. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One 2013;8:e56603

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