Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
Biological ActivityCalmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.
Effect of calmidazolium analogs on calcium influx in HL-60 cells.
Harper and Daly
Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells.
Peppiatt et al.
Citations for Calmidazolium chloride
The citations listed below are publications that use Tocris products. Selected citations for Calmidazolium chloride include:
3 Citations: Showing 1 - 3
JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.
Authors: Kim Et al.
Sci Rep 2018;8:6611
Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors.
Authors: Hook Et al.
J Gen Physiol 2014;144:357
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
Authors: Varadarajan Et al.
PLoS One 2013;8:e56603
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