Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2
production from LPS- and IFN-γ
-induced RAW cells and inhibits TXB2
production via the COX-1 and COX-2 pathways. Inhibits NF-κ
B activation via inhibition of Iκ
degradation and phosphorylation, Iκ
B kinase activation and NF-κ
B nuclear translocation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera.
Lee et al.
Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood.
Ahmad et al.
Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells.
Israf et al.
The citations listed below are publications that use Tocris products. Selected citations for Cardamonin include:
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