Chemical Name: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Biological ActivityChalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera.
Lee et al.
Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood.
Ahmad et al.
Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells.
Israf et al.
Citations for Cardamonin
The citations listed below are publications that use Tocris products. Selected citations for Cardamonin include:
3 Citations: Showing 1 - 3
Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.
Authors: Kim Et al.
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer.
Authors: Jia Et al.
Cell Death Differ 2015;22:298
Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins.
Authors: Yadav Et al.
Br J Pharmacol 2012;165:741
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