Wnt signaling modulator. Potently inhibits Wnt/β
-catenin-dependent transcription in murine ES cells (EC50
= 23 nM) and zebrafish embryos. Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation.
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Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.
Ni et al.